How HHMI Supports Scientists at the Top of Their Game

Time was, America had scientists and inventors in place of movie stars, and the biggest point of national pride was not our latest military score but our latest patent or medical breakthrough. The founding fathers were, by and large, scientists and inventors with enough enlightenment and leisure time to contemplate the democratic ideal. At the turn of the 20th century, newspapers were abuzz with stories on the best and brightest innovations coming down the pike from Edison and Ford. Five hundred million people tuned in to watch the moon landing in 1969. Things are different now, to say the least. Our culture is not nearly as influenced by, or interested in, scientific breakthroughs as it once was.

The Howard Hughes Medical Institute is trying to change that. The giant funder hands out $80 million for biomedical research annually, and lately it has taken a proactive role in encouraging science that contributes to or collaborates with other scientists or other important projects. (See HHMI: Grants for Brain Research and Treatment.)

In 1997, HHMI made Paul Ahlquist, PhD, of the University of Wisconsin, Madison, one of its Investigators. Ahlquist is studying viral replication and virus-host interaction, seeking to uncover evolutionary and functional relationships between seemingly disparate strains of virus. This is brilliant, far-reaching work that, while hammering away at foundational science, contains the potential for insights that would have tremendous positive effects on a wide range of disciplines.

Similarly, David Chan, MD, PhD, of the California Institute of Technology, is delving deep into the physiology of mitochondria, exploring the puzzling conjugations and divisions they undertake over and over inside a cell. He's studying an ancient organelle— it doesn't really get more basic than that, does it? — but think of the potential impact of his work. Think of how many scientists will benefit from his breakthroughs.

These examples show the kind of work HHMI is seeking to encourage: scientists at the top of their game, at big schools with a big stake in the national scientific scene, working on projects that could be serious game changers for scientific discovery in America. (Read HHMI President Robert Tjian's IP profile.)